Impact of an Evidence-Based Antibiotic Protocol on Common Gram-Negative Bacteria's Antibiotic Resistance in a Cardiac Surgical Intensive Care Unit

Abstract Background Based on the analysis of infections and antibiotic usage in years 2013 2014, an evidence-based protocol was developed implemented our cardiac surgical intensive care unit (CSICU). This study intends to impact this new sensitivity profiles common gram-negative bacteria CSICU. Methods The medical records patients who underwent surgery at center, between January 2017 December 2018, were reviewed incidence different hospital-acquired their recorded. antibiotic-sensitivity bacteria, for compared with published data 2014 from department. Results There a significant decrease Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa resistant carbapenems during 2018. colistin-resistant A. baumannii P. also decreased significantly A increase proportion amikacin E. coli B lactam/B lactamase inhibitors occurred. Conclusion Antibiotic stewardship can reverse resistance ICU.